COLLOQUIUM Department of Computer Science and Engineering University of South Carolina Machine Learning and Data Mining in Protein Bioinformatics Jianjun Hu Department of Computer Science and Engineering University of South Carolina Date: April 8, 2011 (Friday) Time: 1430-1520 (2:30-3:20pm) Place: Swearingen 2A31 Abstract Data mining and machine learning have been intensively applied to bioinformatics problems due to the increasingly large amount of data to be analyzed. Computational prediction of protein subcellular localization and protein binding sites are among the major set of functional genomics problems. Here we present our recent work on network based protein localization prediction using diffusion kernel, ensemble localization prediction algorithms, and computational prediction of heme protein binding sites using sequential and structural information. Jianjun Hu is an Assistant Professor in the department of Computer Science and Engineering at the University of South Carolina. He received the Ph.D. degree in Computer Science from Michigan State University in 2004. From 2004 to 2007, he worked as a Postdoc in bioinformatics at Purdue University and the University of Southern California. In 2007, he joined the Department of Computer Science and Engineering at the University of South Carolina. His research interests include bioinformatics, data mining, machine learning, and evolutionary algorithms.